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Conformation of adenosine-5′-triphosphate in the presence of Mg2+ at different pH
- Source :
- Polyhedron. 21:435-438
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- NOESY experiments have been performed on adenosine-5'-triphosphate (ATP) in the presence of 1:1 Mg2+ (MgCl2) at different pH. The results show that H8-H1' and H8-H2' interproton NOE intensities change with pH, with nearly equal intensity at low pH (pH 1.9) and with H8-H2' signal stronger than the H8-H1' signal at higher pH (between 3.7 and 8.5). The H8-H1' and H8-H2' distances and the C4-N9-Cl'-O4' torsion angle (chi) have been measured from random structures of adenosine and ATP. It is concluded that the lower pH allows the formation of a P-gamma-O-Mg2+-N1 bridge and the torsion angle takes a cis conformation accordingly. (C) 2002 Elsevier Science Ltd. All rights reserved.
Details
- ISSN :
- 02775387
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Polyhedron
- Accession number :
- edsair.doi...........a32125d8499c63ceb0262f7d58b33a88