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Selective α-Bromination of β-Keto Esters in Reusable PEG-400 under Mild and Catalyst-Free Conditions
- Source :
- ChemInform. 38
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- An efficient bromination protocol for the synthesis of α-bromo-β-keto esters has been developed. In PEG-400 (poly(ethylene glycol-400)), a variety of β-keto esters were treated with NBS (N-bromosuccinimide) at room temperature to selectively afford the corresponding α-monobromination products in excellent yields. It is noteworthy that the reaction was conducted under mild, environmentally benign and catalyst-free conditions.
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi...........a349acf0afd58b094170da0247d5df47