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Chemistry and Pharmacology of Luliconazole (Imidazole Derivative): A Novel Bioactive Compound to Treat Fungal Infection-A Mini Review

Authors :
Amrita Mishra
Arun K. Mishra
Shweta Verma
Jagdish K. Sahu
Arvind Kumar
Harpreet Singh
Source :
Current Bioactive Compounds. 15:602-609
Publication Year :
2020
Publisher :
Bentham Science Publishers Ltd., 2020.

Abstract

Background: Currently, ringworm treatment drugs include two major categories: first, propylene amine drugs, such as terbinafine, butenafine and naftifine, which exert their bactericidal effects through inhibiting squalene cyclase, causing the lack of ergosterol and accumulation of squalene. The second category of imidazole drugs includes miconazole, econazole, clotrimazole, ketoconazole and bifonazole. Mechanism: These synthetic antifungal agents exhibits their action by inhibiting the lanosterol 14α- demethylation activity of fungal cell, leading to the prevention of the ergosterol synthesis of cell membrane, changing the cell membrane permeability, and resulting in the loss of important intracellular fungal material and causing fungal death. Applications: At present, Imidazole antifungal agents are commonly used drugs in clinical treatment of ringworm with extensive clinical applications. Conclusion: The present review covers the chemistry and detailed pharmacology aspects of luliconazole.

Details

ISSN :
15734072
Volume :
15
Database :
OpenAIRE
Journal :
Current Bioactive Compounds
Accession number :
edsair.doi...........a40a0348be15d0b0654695bdb8f75e1c
Full Text :
https://doi.org/10.2174/1573407214666180717111419