Free Radicals and Human Aging Muscle

Aging is an inevitable biological process, characterized by a general decline in physiological and biochemical functions of major body systems. In the case of the neuromuscular system, reductions in strength and mobility cause a deterioration in motor performance, impaired mobility, and disability. At the cellular level, aging is caused by a progressive decline in mitochondrial function that results in accumulation of reactive oxygen species (ROS). As the level of oxidative stress in skeletal muscle increases with age, advancing age is characterized by an