Der Nachweis von M-Komponenten der Immunglobuline im Speichel von Patienten mit Paraproteinämien

Summary Serum, urine and saliva of forty patients with paraproteinaemia were studied by immunodiffusion and immunoelectrophoresis. In the saliva of twenty-two out of twenty-seven patients with monoclonal IgG, in one out of seven cases with monoclonal IgA, in all four with monoclonal IgM and in one patient with monoclonal lambda-type Bence-Jones-protein in the serum the M-component was also found in the saliva in very small amounts (about 1 mg/100 ml). These results are interpreted and discussed as supporting the hypothesis of local production of immunoglobulins.