Last Word on Viewpoint 'The role of the large airways on smooth muscle contraction in asthma'

To the Editor : Macklem ([3][1]) and Pellegrino and Brusasco ([4][2]) suggest that the change in lung volume from the baseline smooth muscle tone (BSMT) might be largely an artifact. Whatever proportion of the increase in FRC from the BSMT was due to an artifact had no significant effect on the