Bryostatin: A novel asymmetric synthesis of the C27C34 fragment starting from (R)-carvone as chiral template

( R )-Carvone is a suitable chiral template for the synthesis of differently protected (4 S ,6 R ,7 R )-trihydroxy-1-octyne derivatives, the C 27 C 34 fragment of bryostatins. Also other potentially interesting chiral building blocks are described.