Acidic and neutral sialidase in the erythrocytes of patients with Type 2 diabetes: influence on erythrocyte lifespan

Venerando et al reported an increased quantity of sialic acid at the surface of erythrocytes in diabetic patients and associated the increase with decreased activity of neutral sialidase, an enzyme for which they had previously demonstrated a role in physiologic desialylation of red cells.[1][1] In