ChemInform Abstract: The First Synthesis and Molecular Docking Studies of Diastereomerically Pure Substituted 4-Amino-7-hydroxyheptanoic Acids

Diastereoselective synthesis of 4-amino-7-hydroxyheptanoic acids 1 , new GABA analogues, was performed involving reduction of C-3 functionalized 5,6-dihydro-4 H -1,2-oxazines available from nitroethane. Molecular docking studies showed that amino acids of type 1 may bind to GABA transaminase, however, no inhibition was observed in the experiments with the enzyme.