ChemInform Abstract: Development of Chiral Metal Amides as Highly Reactive Catalysts for Asymmetric [3 + 2] Cycloadditions

Highly efficient catalytic asymmetric [3 + 2] cycloadditions using a chiral copper amide are reported. Compared with the chiral CuOTf/Et3N system, the CuHMDS system showed higher reactivity, and the desired reactions proceeded in high yields and high selectivities with catalyst loadings as low as 0.01 mol %.