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A PASE Approach to the Synthesis of Benzimidazopurines as Polycondensed Purine Derivatives
- Source :
- Synthesis. 52:3622-3631
- Publication Year :
- 2020
- Publisher :
- Georg Thieme Verlag KG, 2020.
-
Abstract
- A highly efficient PASE approach to a new class of polycyclic purine derivatives has been proposed. The strategy includes a consecutive reduction, auto-aromatization, and heterocyclization of the initial nitrobenzimidazopyrimidines obtained by a three-component condensation. It was shown that reduction of nitrobenzimidazopyrimidines by metals in acidic media was more efficient than heterogeneous hydro­genation. Novel derivatives of benz[4,5]imidazo[1,2-a]purines were obtained­ in good yields and the proposed structure was confirmed by X-ray crystal structure analysis. The obtained convergent benzimidazopurines combine two relevant medicinal chemistry scaffolds – benz­imidazole and purine.
Details
- ISSN :
- 1437210X and 00397881
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Synthesis
- Accession number :
- edsair.doi...........a6efa7315c7c08eefd840cedad58b877
- Full Text :
- https://doi.org/10.1055/s-0040-1707228