A Double Blind Crossover Comparison of Loperamide with Diphenoxylate in the Symptomatic Treatment of Chronic Diarrhea

Loperamide, a novel antidiarrheal agent, was compared with diphenoxylate in a double blind crossover study of 23 patients with chronic diarrhea of various etiologies. Both agents were found to be capable of controlling or greatly reducing chronic diarrhea. Loperamide was superior to diphenoxylate in its ability to decrease the frequency and improve the consistency of the stools, even at a 2.5-fold lower dose level.