Back to Search
Start Over
H2S as a potential defense against COVID-19?
- Source :
- American Journal of Physiology-Cell Physiology. 319:C244-C249
- Publication Year :
- 2020
- Publisher :
- American Physiological Society, 2020.
-
Abstract
- The outbreak of COVID-19 pneumonia caused by a new coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) is posing a global health emergency and has led to more than 380,000 deaths worldwide. The cell entry of SARS-CoV-2 depends on two host proteins angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). There is currently no vaccine available and also no effective drug for the treatment of COVID-19. Hydrogen sulfide (H2S) as a novel gasotransmitter has been shown to protect against lung damage via its anti-inflammation, antioxidative stress, antiviral, prosurvival, and antiaging effects. In light of the research advances on H2S signaling in biology and medicine, this review proposed H2S as a potential defense against COVID-19. It is suggested that H2S may block SARS-CoV-2 entry into host cells by interfering with ACE2 and TMPRSS2, inhibit SARS-CoV-2 replication by attenuating virus assembly/release, and protect SARS-CoV-2-induced lung damage by suppressing immune response and inflammation development. Preclinical studies and clinical trials with slow-releasing H2S donor(s) or the activators of endogenous H2S-generating enzymes should be considered as a preventative treatment or therapy for COVID-19.
- Subjects :
- 0301 basic medicine
Physiology
business.industry
Inflammation
Cell Biology
Pharmacology
medicine.disease_cause
Entry into host
TMPRSS2
Transmembrane Protease Serine 2
Virus
3. Good health
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Immune system
030220 oncology & carcinogenesis
medicine
Signal transduction
medicine.symptom
business
Coronavirus
Subjects
Details
- ISSN :
- 15221563 and 03636143
- Volume :
- 319
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Cell Physiology
- Accession number :
- edsair.doi...........a7cf3876baf4069db729a83f26cf1ae3