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Discovery of Metabolic Biomarkers Predicting Radiation Therapy Late Effects in Prostate Cancer Patients

Authors :
John Pahira
Amrita K. Cheema
John H. Lynch
Yiwen Wang
Xiaogang Zhong
Gaurav Bandi
Khyati Y. Mehta
Keith J. Kowalczyk
Anatoly Dritschilo
Shreyans K. Jain
Olga A. Timofeeva
Simeng Suy
Smrithi S. Menon
Scott Grindrod
Sean P. Collins
Source :
Advances in Experimental Medicine and Biology ISBN: 9783030222536
Publication Year :
2019
Publisher :
Springer International Publishing, 2019.

Abstract

Patients presenting with prostate cancers undergo clinical staging evaluations to determine the extent of disease to guide therapeutic recommendations. Management options may include watchful waiting, surgery, or radiation therapy. Thus, initial risk stratification of prostate cancer patients is important for achieving optimal therapeutic results or cancer cure and preservation of quality of life. Predictive biomarkers for risks of complications or late effects of treatment are needed to inform clinical decisions for treatment selection. Here, we analyzed pre-treatment plasma metabolites in a cohort of prostate cancer patients (N = 99) treated with Stereotactic Body Radiation Therapy (SBRT) at Medstar-Georgetown University Hospital in a longitudinal, quality-of-life study to determine if individuals experiencing radiation toxicities can be identified by a molecular profile in plasma prior to treatment. We used a multiple reaction mass spectrometry-based molecular phenotyping of clinically annotated plasma samples in a retrospective outcome analysis to identify candidate biomarker panels correlating with adverse clinical outcomes following radiation therapy. We describe the discovery of candidate biomarkers, based on small molecule metabolite panels, showing high correlations (AUCs ≥ 95%) with radiation toxicities, suitable for validation studies in an expanded cohort of patients.

Details

ISBN :
978-3-030-22253-6
ISBNs :
9783030222536
Database :
OpenAIRE
Journal :
Advances in Experimental Medicine and Biology ISBN: 9783030222536
Accession number :
edsair.doi...........a7d28d659b860e802f56d66355f29077
Full Text :
https://doi.org/10.1007/978-3-030-22254-3_11