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Synthesis of novel isoxazole derivatives bearing kojic acid moiety and evaluation of their antimicrobial activity

Authors :
Mahnaz Saraei
Sona Khodabandlou
Source :
Chemistry of Heterocyclic Compounds. 57:823-827
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

A novel series of 3,5-disubstituted isoxazoles bearing kojic acid moiety were synthesized via Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction of terminal alkynes with nitrile oxide formed in situ from the corresponding hydroximoyl chloride. Structures of the synthesized compounds were characterized using spectroscopic analysis data. Antimicrobial activity of the isoxazole conjugates was determined as MIC values by broth microdilution method against different bacteria: Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, and fungi Candida kefyr. The obtained results revealed notable antibacterial and antifungal activities of the compounds.

Details

ISSN :
15738353 and 00093122
Volume :
57
Database :
OpenAIRE
Journal :
Chemistry of Heterocyclic Compounds
Accession number :
edsair.doi...........a8238e724cb0f532ca09d9c905ad8caf
Full Text :
https://doi.org/10.1007/s10593-021-02986-4