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Leukotriene-induced contraction of isolated guinea pig gallbladder (GB) strips

Authors :
Debesh K. Basu
Eldon A. Shaffer
Stephen M. Freedman
John L. Wallace
Source :
Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle ISBN: 9781461364832
Publication Year :
1992
Publisher :
Springer US, 1992.

Abstract

Gallstone disease is a significant health problem; an estimated 15 million adults are affected by this biliary tract disease in North America. Cholesterol gallstone formation is accompanied by impaired GB motility. A later stage is cholecystitis- an inflammatory event which may increase smooth muscle tone, resulting in pain1. In animal models of cholecystitis, significant increases in the levels of arachidonic acid metabolites in GB perfusates has been demonstrated2. These metabolites, comprised of prostanoids (PS) and leukotrienes (LT), have traditionally been associated with many inflammatory processes3. The role of PS in the etiology of cholecystitis and gallstone formation has been well defined. However, to date, little is known regarding the role assumed by the LT’s in these disease states.

Details

ISBN :
978-1-4613-6483-2
ISBNs :
9781461364832
Database :
OpenAIRE
Journal :
Excitation-Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle ISBN: 9781461364832
Accession number :
edsair.doi...........a853aa6f67aafba965fe9579e4e1b227
Full Text :
https://doi.org/10.1007/978-1-4615-3362-7_70