NUCLEAR EXPRESSION OF ARYL HYDROCARBON RECEPTOR PREDICTS DISEASE SPECIFIC SURVIVAL OF UROTHELIAL CARCINOMA OF THE UPPER URINARY TRACT

199 NUCLEAR EXPRESSION OF ARYL HYDROCARBON RECEPTOR PREDICTS DISEASE SPECIFIC SURVIVAL OF UROTHELIAL CARCINOMA OF THE UPPER URINARY TRACT Masaru Ishida*, Eiji Kikuchi, Shuji Mikami, Takeo Kosaka, Akira Miyajima, Makio Mukai, Yasunori Okada, Mototsugu Oya. Tokyo, Japan. INTRODUCTION AND OBJECTIVE: Cigarette smoke contributes to the development of urothelial cancer (UC). The aryl hydrocarbon receptor (AhR), which is the receptor for xenobiotics such as cigarette smoke, induces the CYP1 family, which becomes involved in tumor initiation and progression. AhR overexpression is observed in a few cancers, such as lung and pancreatic cancer, but expression of AhR in UCs, including bladder cancer, has not been investigated. We detected