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Development and Scale-Up of a Continuous Aerobic Oxidative Chan–Lam Coupling

Authors :
Alison Campbell Brewer
David C. Robbins
Joseph R. Martinelli
Nessa Mullane
Philip C. Hoffman
Kobierski Michael Edward
Source :
Organic Process Research & Development. 23:1484-1498
Publication Year :
2019
Publisher :
American Chemical Society (ACS), 2019.

Abstract

Despite the benefits of high atom economy and low cost, aerobic oxidations have found limited use in the synthesis of active pharmaceutical ingredients (APIs) because of safety concerns and poor se...

Subjects

Subjects :
Active ingredient
010405 organic chemistry
Chemistry
Organic Chemistry
Homogeneous catalysis
Continuous manufacturing
010402 general chemistry
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
Chan-Lam coupling
Atom economy
SCALE-UP
Physical and Theoretical Chemistry

Details

ISSN :
1520586X and 10836160
Volume :
23
Database :
OpenAIRE
Journal :
Organic Process Research & Development
Accession number :
edsair.doi...........a920fd86bed4ea2a7093b570bfcd4dda
Full Text :
https://doi.org/10.1021/acs.oprd.9b00125
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