CRT-600.17 DNA Ligase Activity Measuring DNA Repair Determines Atherosclerotic Plaque Instability In Acute Coronary Syndrome

Authors :: Lisiane B. Meira
Ruan M. Elliott
Diana L. Bordin
Michael Mahmoudi
Nikunj Shah
Mark Williams
Clara Forrer-Charlier
Source :: JACC: Cardiovascular Interventions. 10:S56
Publication Year :: 2017
Publisher :: Elsevier BV, 2017.
Abstract: DNA damage and repair activity is increasingly recognized in atherogenesis. By facilitating DNA strand joining by catalyzing phosphodiestere bond formation, DNA ligase is crucial in single/double stranded DNA break repair. We aimed to identify differential DNA ligase activity as well as a

Subjects :: chemistry.chemical_classification
Acute coronary syndrome
DNA ligase
Plaque instability
business.industry
DNA damage
DNA repair
DNA ligase activity
medicine.disease
Molecular biology
chemistry.chemical_compound
chemistry
Medicine
Cardiology and Cardiovascular Medicine
business
Double stranded
DNA

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