Back to Search Start Over

Research on 1-aza two-ring systems

Authors :
L. N. Astakhova
I. M. Skvortsov
I. Ya. Evtushenko
S. N. Kuz'min
E. V. Cheslavskaya
S. P. Voronin
Source :
Chemistry of Heterocyclic Compounds. 16:52-56
Publication Year :
1980
Publisher :
Springer Science and Business Media LLC, 1980.

Abstract

Mixtures of isomeric 5-, 6-, and 7-carbethoxymethyl-1,2-dihydropyrrolizines were obtained by reaction of 1,2-dihydropyrrolizines with ethyl diazoacetate. The effect of the position of the alkyl groups in the two-membered ring on the ratio of isomers in the reaction products is demonstrated. A method for the isolation of 5-carbethoxymethyl-1,2-dihydropyrrolizines from the mixtures of isomers based on the difference in their reactivities in diazo coupling is described. The preferred conformations of the two-membered rings in the 5-carbethoxymethyl-1,2-dihydropyrrolizines are judged from the PMR spectral data.

Details

ISSN :
15738353 and 00093122
Volume :
16
Database :
OpenAIRE
Journal :
Chemistry of Heterocyclic Compounds
Accession number :
edsair.doi...........aa7d43c663074637c94b142ba731527d
Full Text :
https://doi.org/10.1007/bf00475392