Some applications of conformational analysis in organic chemistry

Part 1 of this account deals with the conformational analysis of the diastereomers of RCHXCHXR (R=CH 3 , X=Cl, Br; R=C 6 H 5 X=Br) and of compounds of the type R 2 CHCHR 2 and RR′CHCHRR′ (R and R′ alkyl). These studies are closely related to Mizushima's pioneering work. In part 2, conformational equilibria of geminally substituted phenylcyclohexanes are discussed, including that of phencyclidine [1-phenyl-1(N-piperidino)cyclohexane] as a function of solvent, temperature and protonation and that of the chromium tricarbonyl complexes of phenylcyclohexane and of 1-methyl-1-phenylcyclohexane.