ChemInform Abstract: Regioselectivity in Direct Arylation of Benzanilide Possessing Oxygen Substituent in the Benzoyl Part Using Palladium Without Phosphine Ligand

The arylation of benzanilide (I) possessing ether oxygen(s) proceeds under phosphine-ligand free conditions to afford the para-product (II) and the ortho-product (III) in a similar ratio as in the presence of the P(o-Tol)3 ligand, suggesting that the bulkiness of palladium under phosphine-free conditions is comparable to that under P(o-Tol)3 conditions.