Investigation of clinical factors associated with development of chronic kidney disease and eGFR decline in Japanese patients with type 2 diabetes mellitus

The aim of our study was to investigate clinical factors associated with the development of chronic kidney disease (CKD) in Japanese type 2 diabetes patients diagnosed by the new equation established by the Japanese Society of Nephrology. We analyzed data collected from 653 Japanese patients with type 2 diabetes who were followed at Juntendo University Hospital for 2 years to determine the risk factors for new-onset CKD and 2-year eGFR decline from the baseline. CKD developed de novo in 56 diabetic patients, whereas 288 patients showed no signs of CKD at the end of the 2-year follow-up period. The 2-year cumulative incidence of newly diagnosed cases with CKD was 8.6%. Of these, the transition rate to albuminuria was 73.2%, the proportion of patients who developed low eGFR (