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Synthesis of a 1,2,3-Thiadiazole of Butyl Glycyrrhetinate

Authors :
L. A. Baltina
D. M. Shayakhmetova
T. R. Nugumanov
Source :
Chemistry of Natural Compounds. 55:692-695
Publication Year :
2019
Publisher :
Springer Science and Business Media LLC, 2019.

Abstract

The butyl ester of 3-oxoglycyrrhetinic acid reacted with semicarbazide in EtOH in the presence of NaOAc to produce the 3-semicarbazone, Hurd–Mori cyclization of which gave in 85% yield a 1,2,3-thiadiazole annelated to ring A.

Subjects

Subjects :
Semicarbazide
010405 organic chemistry
Plant Science
General Chemistry
Ring (chemistry)
01 natural sciences
General Biochemistry, Genetics and Molecular Biology
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
Triterpenoid
chemistry
Yield (chemistry)
Organic chemistry
Semicarbazone

Details

ISSN :
15738388 and 00093130
Volume :
55
Database :
OpenAIRE
Journal :
Chemistry of Natural Compounds
Accession number :
edsair.doi...........ace0af618a32ef48ed5d7a4ea485f612
Full Text :
https://doi.org/10.1007/s10600-019-02780-x
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