The effect of adrenaline on sympathetic ganglion cells of bullfrogs

Amphibian sympathetic ganglion cells produce hyperpolarizing and depolarizing responses to adrenaline. Two kinds of adrenergic receptors responsible for the production of these responses appear to occur at different sites on the cell surface. The hyperpolarizing response is produced by changes in the sodium pump, presumably an electrogenic sodium pump, whereas the depolarizing response is produced by changes in the membrane permeability to certain ions.