Structural, Developmental and Functional Heterogeneity of Rat GABAA Receptors

My laboratory has had a long interest in multigene families, starting with our earlier work on the developmental regulation of hemoglobin switching. I have especially been impressed both by the number of multigene families in the vertebrate genome and by their widespread developmental regulation, as exemplified by switching within the globin gene families. Even the lamprey, whose adult hemoglobin, unlike those of higher vertebrates, contains only one type of globin chain, has different forms in its larval and adult stages.