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Three New Metabolites From the Marine-Derived Fungus Aspergillus sp. WHUF03110
- Source :
- Natural Product Communications. 16:1934578X2110550
- Publication Year :
- 2021
- Publisher :
- SAGE Publications, 2021.
-
Abstract
- Two new xanthone derivatives, spinosusones A (1) and B (2), and a new tryptoquivaline analogue, asperdiazapinone G (3), together with nine known compounds (4-12) were isolated from the EtOAc extract of the marine-derived fungus Aspergillus sp . WHUF03110. The structures of 1-3 were determined by spectroscopic analysis, and comparison with literature data. Most of these isolated compounds were evaluated for their antimicrobial activities against ten Gram-negative and seven Gram-positive bacteria, Mycobacterium smegmatis ATCC 607, Candida albicans ATCC SC5314, and C. albicans YY-1-4. Compound 10 displayed strong antibacterial activity against five Gram-positive bacteria ( Bacillus subtilis 168, Staphylococcus aureus ATCC25923, S. aureus NEWMAN, S. aureus USA300, S. aureus NRS 271) with MIC values ranging from 1.0 to 2.0 μg/mL, and displayed moderate antibacterial activity against four Gram-negative bacteria ( Helicobacter pylori 26695, H. pylori G27, H. pylori 159, H. pylori 129) and M. smegmatis ATCC 607 with a MIC value of 8.0 μg/mL.
Details
- ISSN :
- 15559475 and 1934578X
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Natural Product Communications
- Accession number :
- edsair.doi...........adda13771e633839ea025410f1e42445