Current status of the prostaglandins

PIP: This is a general coverage of the entire topic of PGs (prostaglandins). It includes an extensive literature review. The history, nomenclature, biosynthesis, analytical methods of detection, stability, metabolism, pharmacodynamic effects, and clinical uses of PGs are discussed. The discussion of PG biosynthesis is illustrated with chemical structure diagrams showing the progression from prostanoic acid, the parent 20-carbon acid, to various PG analogs. Since natural PGs under both basic and acidic conditions are generally unstable, chemists encounter problems in synthesizing them and physical pharmacists in developing chemically stable dosage forms. The main clinical use for PGs is to induce abortions and labor. PGs also have powerful gastrointestinal, bronchoconstrictive, and antihypertensive properties.