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Highly regioselective and stereoselective synthesis of C-Aryl glycosides via nickel-catalyzed ortho-C–H glycosylation of 8-aminoquinoline benzamides
- Source :
- Chemical Communications. 57:8945-8948
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- C-Aryl glycosides are of high value as drug candidates. Here a novel and cost-effective nickel catalyzed ortho-CAr–H glycosylation reaction with high regioselectivity and excellent α-selectivity is described. This method shows great functional group compatibility with various glycosides, showing its synthetic potential. Mechanistic studies indicate that C–H activation could be the rate-determining step.
- Subjects :
- chemistry.chemical_classification
8-Aminoquinoline
Glycosylation
Stereochemistry
Aryl
Metals and Alloys
Glycoside
Regioselectivity
General Chemistry
Catalysis
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry.chemical_compound
chemistry
Functional group
Materials Chemistry
Ceramics and Composites
Stereoselectivity
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi...........b021a0e653403ceb11aff1e9851d30ba