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MP47-12 MIR-646 IN CLEAR CELL RENAL CARCINOMA CORRELATED WITH TUMOUR METASTASIS BY TARGETING THE NIN ONE BINDING PROTEIN

Authors :
Jian-Ping Che
Yuanyuan Zhang
Junhua Zheng
Min Liu
Wei Li
Source :
Journal of Urology. 193
Publication Year :
2015
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2015.

Abstract

expression profiles for miR-10a and 10b in the nephrectomy and RMB specimens, binary logistic regression models were created for differentiation between local and aggressive disease. From the biopsy samples, the area under the curve, sensitivity, and specificity of this model were 0.818, 63.6, and 76.9, respectively. Decreased cancer specific survival was shown for patients with lower levels of miR-10b at 5 years follow up. CONCLUSIONS: We have identified a panel of 7 miRNA whose expression profiles are statistically different between local and aggressive ccRCC. This is the first study to stratify patients with ccRCC using biopsy tissue alone. The future utility of RMB may be in stratification and prognosis in addition to its current primary use of histologic diagnosis.

Details

ISSN :
15273792 and 00225347
Volume :
193
Database :
OpenAIRE
Journal :
Journal of Urology
Accession number :
edsair.doi...........b171b7a12812648e5bc30af47bd30e71