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Facile Synthesis of Spirocyclic Tetrahydroquinolines via C(sp3)–H Functionalization in a Cascade Redox Process
- Source :
- Synthesis. 54:1309-1320
- Publication Year :
- 2021
- Publisher :
- Georg Thieme Verlag KG, 2021.
-
Abstract
- An environmentally benign cascade redox process was developed for the efficient construction of the pharmaceutically significant spirocyclic tetrahydroquinolines via sequential SNAr/Knoevenagel condensation/[1,5]-hydride transfer/cyclization. This green transformation has the features of being catalyst-free, additive-free, operationally simple, and has high step- and atom-economy.
Details
- ISSN :
- 1437210X and 00397881
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Synthesis
- Accession number :
- edsair.doi...........b1cab1fe9f4f99d96b9142bf3e9b5da9