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Impact on spina bifida screening of shifting prenatal Down syndrome maternal serum screening from the second trimester to the first
- Source :
- Prenatal Diagnosis. 37:673-679
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Objectives Shifting screening for trisomy 21 to the first trimester has resulted in the loss of maternal serum alpha-fetoprotein screening for spina bifida. The aim of this study was to study the impact on open spina bifida prenatal screening. Study design We reviewed prenatally diagnosed cases of spina bifida over three years: 2009 (only second-trimester screening, MSM2T), 2010 (transient period) and 2011 (majority first-trimester screening, MSM1T). Cases were assigned to three groups based on maternal serum markers (MSM2T, MSM1T and 'not performed'). Gestational age at diagnosis of spina bifida was compared between these three groups and between the years 2009 and 2011. Results Median gestational ages at diagnosis of the 742 spina bifida cases between the three groups were 22 weeks [18+6 -23], 22+1 weeks [21+3 -23] and 21+4 weeks [14+1 -23], respectively (P Conclusion Loss of maternal serum alpha-fetoprotein had a tangible effect on the gestational age at diagnosis of spina bifida and resulted in a decrease of 25% of cases of spina bifida detected before 20 weeks. © 2017 John Wiley & Sons, Ltd.
- Subjects :
- congenital, hereditary, and neonatal diseases and abnormalities
Pediatrics
medicine.medical_specialty
Down syndrome
Pregnancy
030219 obstetrics & reproductive medicine
Obstetrics
business.industry
Spina bifida
Obstetrics and Gynecology
Gestational age
Retrospective cohort study
medicine.disease
nervous system diseases
03 medical and health sciences
0302 clinical medicine
Second trimester
medicine
Gestation
030212 general & internal medicine
Trisomy
business
Genetics (clinical)
Subjects
Details
- ISSN :
- 01973851
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Prenatal Diagnosis
- Accession number :
- edsair.doi...........b1e1ee7af57014eb3afa0b5a0f65f451