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Effect of selective CCK1 receptor antagonism on accommodation and tolerance of intestinal gas in functional gut disorders
- Source :
- Journal of Gastroenterology and Hepatology. 31:288-293
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- BACKGROUND Participants with functional gut disorders develop gas retention and symptoms in response to intestinal gas loads that are well tolerated by healthy subjects. To determine the role of cholecystokinin (CCK1 ) receptors on gas transit and tolerance in women with functional gut disorders. METHODS In 12 healthy women, and 24 women with functional gut disorders (12 dyspepsia and 12 constipation-predominant irritable bowel syndrome) gas was infused into the jejunum at 12 mL/min for 3 h with simultaneous duodenal lipid infusion (intralipid 1 kcal/min), while measuring anal gas evacuation and abdominal symptoms on a 0-6 score scale. Triple-blind paired studies during iv infusion of dexloxiglumide (2.5 mg/kg bolus plus 5 mg/kg h continuous infusion), a selective CCK1 inhibitor, or saline (control) were performed in random order. RESULTS During saline infusion participants with functional gut disorders developed significantly greater gas retention and abdominal symptoms than healthy subjects (394 ± 40 mL vs 265 ± 35 mL and 2.8 ± 0.3 vs 1.9 ± 0.4 highest abdominal symptom score, respectively; P
- Subjects :
- medicine.medical_specialty
Hepatology
business.industry
medicine.medical_treatment
Dexloxiglumide
Gastroenterology
medicine.disease
Jejunum
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Bolus (medicine)
030220 oncology & carcinogenesis
Internal medicine
medicine
030211 gastroenterology & hepatology
medicine.symptom
business
Receptor
Flatulence
Saline
Irritable bowel syndrome
Cholecystokinin
Subjects
Details
- ISSN :
- 08159319
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Journal of Gastroenterology and Hepatology
- Accession number :
- edsair.doi...........b1f84c5462d3f1e5849c206475515786
- Full Text :
- https://doi.org/10.1111/jgh.13177