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IMPROVED METHOD FOR DEMETHYLATION OF NITRO- CATECHOL METHYL ETHERS

Authors :
Paula C. Alves
David Alexander Learmonth
Source :
Synthetic Communications. 32:641-649
Publication Year :
2002
Publisher :
Informa UK Limited, 2002.

Abstract

Several nitro-catechol compounds, useful as inhibitors of COMT were obtained in excellent yield and purity via an improved procedure for demethylation of the corresponding methyl ethers using aluminium chloride and pyridine in ethyl acetate.

Subjects

Subjects :
Catechol
Aluminium chloride
Chemistry
Organic Chemistry
Ethyl acetate
Improved method
chemistry.chemical_compound
nervous system
Yield (chemistry)
Pyridine
Nitro
medicine
Organic chemistry
medicine.drug
Demethylation

Details

ISSN :
15322432 and 00397911
Volume :
32
Database :
OpenAIRE
Journal :
Synthetic Communications
Accession number :
edsair.doi...........b2bd64b1a33862e909f457b0c76fce4d
Full Text :
https://doi.org/10.1081/scc-120002413
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