Pathophysiology of Clostridium difficile-related intestinal disease

Pseudomembranous colitis (pmc) is the most severe form and probably the last stage [35] of a spectrum of acute intestinal diseases due mainly to antibiotic administration and with in situ proliferation of toxigenic Clostridium difficile [7],[19].This pathogen seems also to be responsible for cases of pmc not linked to antibiotherapy [7,42](Table 1).