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Poly(ionic liquid)-Gated CuCo2S4 for pH-/Thermo-Triggered Drug Release and Photoacoustic Imaging
- Source :
- ACS Applied Materials & Interfaces. 12:9000-9007
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- A novel hybrid drug nanocarrier is developed with CuCo2S4 nanoparticles as the core to be encapsulated by poly(ionic liquid) (PIL), that is, poly(tetrabutylphosphonium styrenesulfonate) (P[P4,4,4,4][SS]), as the shell. Doxorubicin (DOX) is loaded onto the PIL shell via electrostatic attraction involving amine in DOX and styrenesulfonate in PIL. pH- and thermal-responsive characteristics of P[P4,4,4,4][SS] endow the multifunctional hybrid nanocarrier system DOX-CuCo2S4@PIL with sensitive dual-stimuli-triggered drug release behaviors. The CuCo2S4 core converts near-infrared (NIR) irradiation into thermal energy to trigger the shrinkage of the PIL shell, which subsequently promotes drug release, and the pH-responsive release of DOX involves pH-sensitive electrostatic interaction of the PIL shell with DOX. A favorable controlled release of 90.5% is achieved under pH/thermo dual stimuli. In vitro experiments with MCF-7 cells well demonstrated that the drug release is controlled by the acidic intracellular environment with NIR irradiation. The CuCo2S4 core also serves as a photoacoustic (PA) imaging contrast agent, as demonstrated by in vivo treatment of the MCF-7-carrying mice.
- Subjects :
- Materials science
Nanoparticle
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Controlled release
0104 chemical sciences
law.invention
chemistry.chemical_compound
Magazine
chemistry
law
In vivo
Ionic liquid
Biophysics
medicine
General Materials Science
Amine gas treating
Doxorubicin
Nanocarriers
0210 nano-technology
medicine.drug
Subjects
Details
- ISSN :
- 19448252 and 19448244
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi...........b3eec465c63a6185f7731793a5be2ed2