ChemInform Abstract: Microwave-Assisted Diels-Alder Reaction of 2H-Pyran-2-ones with Maleimides Towards Fused Bicyclo[2.2.2]octenes

An efficient, green access to functionalized and highly constrained heteropolycyclic derivatives via a microwave-assisted cycloaddition reaction is reported. The double Diels-Alder reaction of a series of 2H-pyran-2-ones with maleimide and its N-substituted derivatives takes place in an aqueous mixture (and in some cases as neat reaction) to give a variety of fused bicyclo[2.2.2]oct-7-enes.