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An efficient, expeditious, and diastereoselective one-pot pseudo-five-component reaction for the synthesis of new bis-Betti bases under catalyst-free conditions
- Source :
- Tetrahedron Letters. 53:3086-3090
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- A novel, diastereoselective, one-pot synthesis of new bis-Betti bases via condensation of dihydroxynaphthalene, two equivalents of aryl aldehydes, and two equivalents of 3-amino-5-methylisoxazole is reported. Conversion into the adducts was almost quantitative without the use of solvent or catalyst. The reaction conditions are very simple and enable easy isolation of the product.
Details
- ISSN :
- 00404039
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi...........b5541f4b26cc386dd4e1f01721aaa01f