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Outcomes for paediatric acute leukaemia patients admitted to the paediatric intensive care unit
- Source :
- European Journal of Pediatrics. 181:1037-1045
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Children with acute leukaemia (AL) are a high-risk population for infections and life-threatening conditions requiring paediatric intensive care unit (PICU) admission, presenting an increased mortality rate. A few literature exists about PICU outcomes in this kind of patients, especially with haematopoietic stem cell transplant (HSCT) background. We investigated the clinical and epidemiological characteristics of these patients as well as their outcomes. A retrospective, single-centre analytical/observational study was conducted from January 2011 to December 2018 in the PICU of a tertiary care hospital. AL patients from 28 days to 18 years old admitted to the PICU were included, excluding those with histories of HSCT or CAR T-cell therapy. We collected epidemiological and clinical characteristics, laboratory and microbiology results and outcomes. Forty-three patients with AL required urgent admission (35 lymphoblastic and 8 myeloblastic) for 63 different episodes. The main reasons were sepsis (21, 33.3%), hyperleukocytosis (12, 19%), respiratory failure (11, 17.5%) and seizures (8, 12.7%). Nineteen (30.2%) required inotropic support, and fifteen (23.8%) required mechanical ventilation. Three patients died at the hospital (3/43, 6.9%). Sixty-day mortality was 9.3%, and 1-year mortality was 13.9%. There was no differences regarding the type of AL and 60-day mortality (log-rank 2.652, p = 0.103). Conclusion: In our study, the main cause of admission for AL patients was infection, which was associated to more severity and longer hospital admission.
- Subjects :
- Mechanical ventilation
medicine.medical_specialty
education.field_of_study
Pediatrics
business.industry
medicine.medical_treatment
Mortality rate
Population
medicine.disease
Sepsis
Respiratory failure
Pediatrics, Perinatology and Child Health
Epidemiology
medicine
Observational study
education
business
Critical Care Outcomes
Subjects
Details
- ISSN :
- 14321076 and 03406199
- Volume :
- 181
- Database :
- OpenAIRE
- Journal :
- European Journal of Pediatrics
- Accession number :
- edsair.doi...........b57d138ac91700d6ce38f3f2eb22d0ae