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A comparative multi-assay approach to study the toxicity behaviour of Eu2O3 nanoparticles

Authors :
Rajeev Kumar
Ahmad Umar
Priyanka Sharma
Sruthi Ann Alex
Savita Chaudhary
S.K. Mehta
Sandeep Kumar
Amitava Mukherjee
Source :
Journal of Molecular Liquids. 269:783-795
Publication Year :
2018
Publisher :
Elsevier BV, 2018.

Abstract

Europium oxides (Eu2O3) nanoparticles are extensively employed in diverse areas ranging from bioimaging to chemical sensing. However, still there is significant lack of information regarding their toxic behaviour on humans and the environment. The endeavor of this work is to develop structural/toxicity correlations for bare and surface functionalized Eu2O3 nanoparticles synthesized by low-temperature colloidal route. The detailed investigations revealed that Eu2O3 nanoparticles concentration have significant effect on the in vitro toxicity. On the basis of antibacterial, antimicrobial assays and assessment of the genotoxicity using Allium cepa and molecular studies on human blood DNA, it was discovered that surface modification of nanoparticles is an important parameter for reducing the toxicity of Eu2O3 nanoparticles. The phytotoxicity of the prepared nanoparticles has also been compared by the seed germination assay with wheat, green grams, and black chickpeas. The detailed results revealed the mechanism of Eu2O3 nanoparticles in vitro toxicity.

Details

ISSN :
01677322
Volume :
269
Database :
OpenAIRE
Journal :
Journal of Molecular Liquids
Accession number :
edsair.doi...........b5f28e2b271f34929b74b74577180a19