Back to Search
Start Over
Synthesis of Vixotrigine, a Use-Dependent Sodium Channel Blocker. Part 1: Development of Bulk Supply Routes to Enable Proof of Concept
- Source :
- Organic Process Research & Development. 24:2802-2813
- Publication Year :
- 2020
- Publisher :
- American Chemical Society (ACS), 2020.
-
Abstract
- Two syntheses of vixotrigine are reported. Route 1, adapted from the medicinal chemistry route, enabled rapid delivery of drug substance for clinical development. Route 2, which was developed to ad...
Details
- ISSN :
- 1520586X and 10836160
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Organic Process Research & Development
- Accession number :
- edsair.doi...........b6912304c8c05f1fa22e5aed2df15343
- Full Text :
- https://doi.org/10.1021/acs.oprd.0c00382