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Feasibility of tacrolimus, methotrexate, and prednisolone as a graft-versus-host disease prophylaxis in non-T-cell-depleted haploidentical hematopoietic stem cell transplantation for children
- Source :
- Clinical Transplantation. 25:892-897
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- In this study, we evaluated the feasibility of our graft-versus-host disease (GVHD) prophylaxis with tacrolimus, methotrexate, and prednisolone in non-T-cell-depleted haploidentical hematopoietic stem cell transplantation (HSCT) for children. Twenty-one consecutive patients including those with hematological malignancies (n = 11), solid tumors (n = 7), and non-malignancies (n = 3) were analyzed. Myeloablative and reduced intensity conditionings were carried out in 5 and 16 patients, respectively, and both of the regimens contained anti-human T-lymphocyte immunoglobulin. Twenty (95%) of the 21 patients achieved primary engraftment. Acute GVHD of grades II-IV and III-IV were observed in nine (47%) and one (5%) patient, respectively, all of which were controllable by steroids. Chronic GVHD was observed in eight (51%) of the 17 evaluable patients, and one of them developed steroid refractory chronic GVHD. Treatment-related mortality occurred in three patients (15%), as a result of acute pancreatitis, chronic GVHD, and EB virus associated lymphoproliferative disease. The median follow-up of the 13 survivors was 24 months, and the two-yr probability of overall survival was 68%. The Karnofsky performance scale score of the 13 survivors was 100%. These results indicated the feasibility of our GVHD prophylaxis in non-T-cell-depleted haploidentical HSCT for children.
- Subjects :
- Transplantation
medicine.medical_specialty
business.industry
medicine.medical_treatment
Hematopoietic stem cell transplantation
medicine.disease
Gastroenterology
Tacrolimus
Histocompatibility
Surgery
surgical procedures, operative
Graft-versus-host disease
immune system diseases
Internal medicine
Prednisolone
Medicine
Methotrexate
business
Survival rate
medicine.drug
Subjects
Details
- ISSN :
- 09020063
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Clinical Transplantation
- Accession number :
- edsair.doi...........b6deafa0a2861b4e898c3348e0227a98