Dog and Swine as Models for Testing Indomethacin Induced Gastrointestinal Irritation

Indomethacin is a popular anti-inflammatory agent. One of its side-effects is gastrointestinal irritation. For the development of less irritating drug formulations it is useful to have a suitable animal model. The aim of the present study was to test the domestic swine (Yorkshire) and beagle dog for this purpose. According to previous studies the alimentary canal of the omnivorous swine may resemble human more than that of the beagle dog (Mount and Ingram 1971).