Targeting FOXOs to slow aging

The key importance of FOXO transcription factors and related pathways in the process of aging renders them compelling targets in the quest for compounds that could slow down the aging process. In this review, we give a brief overview of what we know about the role of FOXO proteins in aging and longevity and describe how this knowledge might be of value in developing future therapies aimed at extending lifespan and health span in people. Given the potential of FOXO proteins to impact on a variety of disorders such as cancer, diabetes, neurodegeneration or immune system dysfunction, novel therapeutic approaches based FOXO-targeting strategies are expected to be a fertile area of research in the near future.