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Complete genome sequence of Streptomyces spongiicola HNM0071T, a marine sponge-associated actinomycete producing staurosporine and echinomycin
- Source :
- Marine Genomics. 43:61-64
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Streptomyes spongiicola HNM0071T is a novel marine sponge-associated actinomycete with potential to produce antitumor agents including staurosporine and echinomycin. Here, we present the complete genome sequence of S. spongiicola HNM0071, which consists of a linear chromosome of 7,180,417 bp, 5669 protein coding genes, 18 rRNA genes, and 66 tRNA genes. Twenty-seven putative secondary metabolite biosynthetic gene clusters were found in the genome. Among them, the staurosporine and echinomycin gene clusters have been described completely. The complete genome information presented here will enable us to investigate the biosynthetic mechanism of two well-known antitumor antibiotics and to discover novel secondary metabolites with potential antitumor activities.
- Subjects :
- 0106 biological sciences
Whole genome sequencing
Genetics
0303 health sciences
Aquatic Science
Secondary metabolite
Ribosomal RNA
Echinomycin
Biology
010603 evolutionary biology
01 natural sciences
Genome
03 medical and health sciences
chemistry.chemical_compound
chemistry
Transfer RNA
medicine
Staurosporine
Gene
030304 developmental biology
medicine.drug
Subjects
Details
- ISSN :
- 18747787
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Marine Genomics
- Accession number :
- edsair.doi...........b73fc9a0eb9a302676f9965379376a0f