Advancement and Future Perspectives of Prostate Cancer Treatment by Using Plant Bio-actives: A Review

Prostate cancer (PCa) is the world's second most lethal and hateful disease in people. Even while chemotherapy medications have made considerable progress against cancer disease, the body still has to deal with their toxic side effects. In order to produce anticancer medicines with the lowest cost and treatment time, mostly people are using mechanistic techniques. In addition to chemotherapy advanced treatment techniques are also used in clinical practices, and they have an excellent healing results by enhancing patient survival rates. The social care net faces serious challenges because of the lack and high cost of modern therapeutic techniques. The side effects of chemotherapeutic drugs and expensive advance techniques triggered the patient interest towards phytochemicals drugs which indicate that nature always attracts human to fulfill their medical needs at very low cost. The pharmaceutical industries are showing strong interest in recent research, which has led to the addition of a quite large number of phyto-medicines in PCa therapeutic practices. Currently, several experimental epidemiological and clinical research reports confirmed that plant bio-actives play a significant role in PCa prevention by using different mechanistic ways such as suppressing adhesion, anti-angiogenesis, pro-apoptosis, anti-proliferation, invasion and migration. This review systematically highlighted various strategies to treat PCa and advances in research by using different bioactive plant extracts and isolated components that have been tested for PCa therapy along with corresponding clinical and epidemiological studies.