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EGFR-targeted delivery of DOX-loaded Fe3O4@polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy
- Source :
- International Journal of Nanomedicine. 12:2899-2911
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Multifunctional nanocomposites that have multiple therapeutic functions together with real-time imaging capabilities have attracted intensive concerns in the diagnosis and treatment of cancer. This study developed epidermal growth factor receptor (EGFR) antibody-directed polydopamine-coated Fe3O4 nanoparticles (Fe3O4@PDA NPs) for magnetic resonance imaging and antitumor chemo-photothermal therapy. The synthesized Fe3O4@PDA-PEG-EGFR-DOX NPs revealed high storage capacity for doxorubicin (DOX) and high photothermal conversion efficiency. The cell viability assay of Fe3O4@PDA-PEG-EGFR NPs indicated that Fe3O4@ PDA-PEG-EGFR NPs had no cell cytotoxicity. However, Fe3O4@PDA-PEG-EGFR-DOX NPs could significantly decrease cell viability (~5% of remaining cell viability) because of both photothermal ablation and near-infrared light-triggered DOX release. Meanwhile, the EGFR-targeted Fe3O4@PDA-PEG-EGFR-DOX NPs significantly inhibited the growth of tumors, showing a prominent in vivo synergistic antitumor effect. This study demonstrated the potential of using Fe3O4@PDA NPs for combined cancer chemo-photothermal therapy with increased efficacy.
- Subjects :
- education
Biophysics
Pharmaceutical Science
Bioengineering
Nanotechnology
macromolecular substances
02 engineering and technology
010402 general chemistry
01 natural sciences
Biomaterials
In vivo
Drug Discovery
medicine
Doxorubicin
Epidermal growth factor receptor
Viability assay
Nanocomposite
biology
Chemistry
Organic Chemistry
technology, industry, and agriculture
Cancer
General Medicine
Photothermal therapy
021001 nanoscience & nanotechnology
medicine.disease
0104 chemical sciences
Cancer research
biology.protein
0210 nano-technology
Fe3o4 nanoparticles
medicine.drug
Subjects
Details
- ISSN :
- 11782013
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- International Journal of Nanomedicine
- Accession number :
- edsair.doi...........b8ee7835a52364886214d945743b7c8b
- Full Text :
- https://doi.org/10.2147/ijn.s131418