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Cidofovir peptide conjugates as prodrugs
- Source :
- Journal of Organometallic Chemistry. 690:2673-2678
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Cidofovir-based compounds having an amino acid, dipeptide or tripeptide attached to a cidofovir or cyclic cidofovir framework. The compounds show enhanced oral bioavailability and increased binding to the PepT1 transporter. The present invention also provides compositions and methods for treating virus infections, and a method of preparing cidofovir.
- Subjects :
- chemistry.chemical_classification
Dipeptide
Chemistry
animal diseases
viruses
Organic Chemistry
virus diseases
Peptide
Transporter
Tripeptide
biochemical phenomena, metabolism, and nutrition
respiratory system
Prodrug
Biochemistry
Bioavailability
Amino acid
Inorganic Chemistry
chemistry.chemical_compound
Materials Chemistry
Physical and Theoretical Chemistry
Cidofovir
Subjects
Details
- ISSN :
- 0022328X
- Volume :
- 690
- Database :
- OpenAIRE
- Journal :
- Journal of Organometallic Chemistry
- Accession number :
- edsair.doi...........b8fb703f6d1751bd26340ad3d6a14dd7
- Full Text :
- https://doi.org/10.1016/j.jorganchem.2005.03.004