THU0064 Clinical signification of anti-ku antibody

Background The Ku autoantigen is a DNA binding factor consisting of 70 and 80 kDa protein which form a heterodimer involved in repair of ds DNA breaks. Since the original description of anti-Ku antibody in patients with polymyositis-scleroderma overlap syndrome, this antibody has been showed to be associated with several autoimmune diseases. Objectives To describe clinical features of 8 patients with anti-KU antibody. Methods Results Conclusion anti-Ku antibody is not specific of a connective tissu disease and can also be observed in patients without any autoimmune disease (n°7). In addition to previous described association, anti-Ku antibody can also be present in Wegener granulomatosis and idiopathic Raynaud’s phenomen. Two of our patients had an evaluative cancer (n°5 and 8) and one (n°7) presented a stomach neoplasm 3 years before the detection of anti-Ku antibody. This finding needs further investigations to assess if anti-Ku antibody can be associated with or predictive of a neoplasm.