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Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy
- Source :
- Nano Research.
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Ferroptosis is a newly form of regulated cell death, which has attracted great attention for tumor therapy. Herein, we prepared nanoscale coordination polymer Fe-NQA particles to deliver iron and NQA (vitamin K3 derivative) into tumor cells, which synergistically promoted ferroptotic therapy for inhibiting tumor growth, preventing metastasis, and overcoming radioresistance.
- Subjects :
- Coordination polymer
Ferroptosis
Vitamin K3
Tumor therapy
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
medicine.disease
01 natural sciences
Atomic and Molecular Physics, and Optics
0104 chemical sciences
Metastasis
chemistry.chemical_compound
chemistry
Radioresistance
Cancer research
medicine
General Materials Science
Tumor growth
Electrical and Electronic Engineering
0210 nano-technology
Derivative (chemistry)
Subjects
Details
- ISSN :
- 19980000 and 19980124
- Database :
- OpenAIRE
- Journal :
- Nano Research
- Accession number :
- edsair.doi...........b95ce7fb71328dd017aa1a396262d01f